PRP should be produced in clinic using commercially available PRP kits. There are a large number of PRP production systems available. With the increasing number of clinics offering PRP treatments, there are almost an equal number of PRP production systems being used. All clinics claim their PRP is the best!
Till more recently few researchers have focussed on what makes for a good PRP system. Magalon and colleagues are based at institutions located in Marseille, France and published a paper in 2016 where they proposed the DEPA classification of PRP. The DEPA system attempts to provide a basis for standardisation of PRP use and an analysis of commercial PRP preparation systems used in various clinics claiming to offer PRP treatments for hair loss.
The DEPA classification comprises:
- D – dose of injected platelets
- E – efficiency of production i.e. the proportion of platelets that are left undamaged by the preparation process
- P – purity of the platelets i.e. whether they are mixed with other cells found in whole blood such as red blood cells
- A – the presence of an activation step using calcium chloride or thrombin that has been shown to yield a higher concentration of cytokines and growth factors in the area of treatment.
Under each of these headings Magalon and his colleagues proposed a scoring system for how well a PRP preparation system fares. The table below shows the scoring system they devised:
|DEPA Classification System|
|Dose of injected platelets (billions)||Efficiency of process (platelet recovery rate %)||Purity of PRP (relative composition in platelets %)||Activation Process
(YES or NO)
(Very high dose)
(Whole Blood PRP)
The next time you consider getting PRP treatment for hair loss make sure you ask the clinic whether they know the DEPA classification for their PRP system. The vast majority of clinics will not know what DEPA even stands for, let alone what the DEPA classification of their PRP kits are.
At Rejuvence Clinic we use Magellan TruPRP. The DEPA classification for our PRP kit has been based on two separate studies that have measured the number of platelets, the percentage platelet recovery rate as well as the relative composition as per the DEPA classification. Magellan scored ACC in a study published by Kushida and colleagues in 2014. Magellan scored BCC in a separate study published by Castillo and colleagues in 2011. Both studies demonstrated an excellent dose of platelets but a low platelet recovery percentage and a mixed PRP sample.
The dose of platelets is likely to be the most critical aspect of any PRP preparation. If the dose of platelets isn’t high enough, PRP will not produce positive results regardless of platelet recovery and the purity of PRP produced. This has been established by the majority of researchers.
In the case of Magellan, although the percentage recovery rate of platelets may be lower than some of its competitors, the dose of platelets is so high that the net result is that it still yields a much better PRP preparation. No commercially available PRP kits come close to having a ‘AAA’ DEPA classification. Hence a compromise has to be accepted. At Rejuvence we believe that Magellan provides the best compromise.
If you are considering getting PRP for hairloss make sure you do your homework and ask the clinic about the DEPA classification for their PRP kits and how do they justify using them.
At Rejuvence Clinic we believe in transparency and ensuring our clients know exactly what we are offering them. In Magellan TruPRP we believe we have the best compromise in terms of PRP kits and we have results to back this up.
For further information on PRP treatments for hair loss at Rejuvence Clinic have a look at our section on PRP for hair loss.
If you are serious about getting PRP treatment for hair loss make sure you give us a call on: 0207 531 6600.
- Semsarzadeh, Khetarpal. Platelet Rich Plasma and Stem Cells for Hair Growth: A Review of the Literature. Aesthet Surg J. 2019 May 20. pii: sjz146. doi: 10.1093/asj/sjz146. [Epub ahead of print]
- Magalon J, Chateau AL, Bertrand B, Louis ML, Silvestre A, Giraudo L, Veran J, Sabatier F. DEPA classification: a proposal for standardising PRP use and a retrospective application of available devices. BMJ Open Sport Exerc Med. 2016 Feb 4;2(1):e000060. eCollection 2016.
- Kushida S, Kakudo N, Morimoto N et al. Platelet and growth factor concentrations in activated platelet-rich plasma: a comparison of seven commercial separation systems. J Artif Organs 2014;17:186–92. 10.1007/s10047-014-0761-5
- Castillo TN, Pouliot MA, Kim HJ et al. Comparison of growth factor and platelet concentration from commercial platelet-rich plasma separation systems. Am J Sports Med 2011;39:266–71. 10.1177/0363546510387517