Autologous Exosomes (Exosmart™) – Advanced PRP Therapy for Hair Loss
Hair loss can be frustrating and distressing for both men and women. At Rejuvence Clinic, we are proud to introduce an advanced regenerative treatment using your own blood – autologous exosomes isolated from Platelet Rich Plasma (PRP) with the Exosmart™ system – to help combat male and female pattern hair loss (androgenetic alopecia). This cutting-edge therapy builds on the success of PRP hair treatments by concentrating the most powerful healing components of your blood to stimulate hair growth in a natural, safe way. It’s a CE-MDR certified breakthrough that we’re excited to be the first clinic in the UK to offer. In this article, we’ll explain in clear, patient-friendly terms what Exosmart exosome therapy is and how it can benefit you.
At Rejuvence Clinic we combine advanced PRP with Exosmart™ technology – using your own blood’s healing factors to rejuvenate thinning hair.
What Are Autologous Exosomes from PRP, and How Can They Help with Hair Loss?
Autologous exosomes are tiny “messenger” particles derived from your own platelets in a PRP sample. Platelets (the blood cells known for healing and clotting) release these microscopic packages – called exosomes – which are loaded with growth factors, proteins, and genetic signals that stimulate cell repair and regeneration. In the context of hair loss, these exosomes act as potent boosters for hair follicles. They can activate dormant hair follicles, prompting them to start growing hair again, and they deliver a concentrated dose of growth signals to existing follicles to produce thicker, healthier hair strands . Additionally, platelet exosomes significantly improve scalp health by increasing angiogenesis, meaning they promote the formation of new blood vessels in the scalp . This improved circulation enhances the delivery of nutrients and oxygen to the hair roots, creating a more nourishing environment for hair growth.
Because these exosomes come from your own blood (autologous), the therapy is extremely safe and biocompatible. There is no risk of immune rejection or allergic reaction that might occur with donor-derived products . In essence, autologous exosome therapy harnesses and amplifies your body’s natural healing power to fight hair thinning. The regenerative effects of platelet-derived exosomes are well documented – they help modulate inflammation, stimulate tissue repair, and encourage new blood vessel formation . All of these effects are beneficial in androgenetic alopecia, where hair follicles gradually miniaturize. By counteracting inflammation around follicles and delivering growth factors directly to them, exosomes can reinvigorate the follicles and prolong their growth phase, helping to reduce shedding and promote new hair growth in both men and women.
What Is Exosmart and How Is the Treatment Performed?
Exosmart™ is a specialized medical device and system for concentrating autologous exosomes from a patient’s PRP. In practical terms, it’s the technology we use to extract that “pure boost” of healing exosomes from your blood sample. The treatment procedure is straightforward and patient-friendly. First, we perform a routine blood draw (about 60 mL, roughly a few tablespoons) – similar to a standard blood test. This blood is immediately processed in a centrifuge to isolate platelet-rich plasma (PRP), separating the platelets from other blood components. We usually obtain roughly 30 mL of PRP/plasma from this step .
Next comes the Exosmart magic: the PRP is passed through a 15 kDa ultrafiltration membrane in the Exosmart device. This advanced filter has ultra-fine pores (~5 nm) that trap the exosomes and other beneficial microscopic vesicles while allowing unwanted free fluids and proteins to pass through . By the end of this step, the PRP volume is reduced to about ~6 mL of concentrated exosome-rich solution . In other words, we’ve taken the growth factors and vesicles from your 60 mL blood sample and concentrated them into just a few milliliters – a ~5× enrichment of exosomes compared to the original PRP volume . Not only does Exosmart concentrate what was already in the PRP, it also uses gentle mechanical shear forces to stimulate the platelets to release even more exosomes during processing . This unique feature boosts exosome yield by an additional 30–40%, meaning we get a significantly higher number of those regenerative packets than standard PRP preparation alone . The entire processing is done on-site and takes around 30 minutes from start to finish , making it a convenient point-of-care procedure while you wait.
Once we have this high-potency exosome concentrate, the final step is the application to your scalp. Typically, our practitioner will inject the 6 mL of exosome solution into the areas of the scalp affected by hair thinning (for example, the crown or hairline) using very fine needles or an automated injector device – much like a regular PRP injection procedure. We use numbing or cooling as needed to keep you comfortable; most patients describe the sensation as a series of tiny pinches. After treatment, there’s minimal downtime – you might have some mild soreness or redness on the scalp for a day, but there is no surgery or scarring involved. You can resume normal activities almost right away. Over the following weeks, the injected exosomes will begin communicating with your hair follicles, triggering repair and growth processes that gradually lead to reduced hair loss and new growth.
Can Exosmart Be Combined with Magellan TruPRP™ and Angel Arthrex™?
Yes, absolutely – in fact, we believe combining Exosmart with these advanced PRP systems yields the best results. At Rejuvence Clinic we have a three-tiered PRP service, and we are authorized providers of the Magellan TruPRP™ (Level II) and Angel Arthrex™ (Level III) PRP systems . These systems are state-of-the-art centrifuge machines that produce very high concentration PRP with excellent platelet yield and purity . Using Magellan or Angel to prepare your PRP means we start with a super-rich platelet sample (much higher platelet counts than basic PRP kits). This high-quality PRP is the perfect input for the Exosmart process – the more platelets we have initially, the more exosomes we can ultimately harvest.
In practice, combining Exosmart with Magellan or Angel is seamless. We draw your blood and let the Level II/III PRP machine do its work to concentrate platelets. Then that high-potency PRP is fed into the Exosmart filter to isolate the exosomes. The result is an autologous exosome product that is derived from top-tier PRP. For you as a patient, this combination means you are getting the benefits of both: the growth factors and cytokines from a premium PRP, plus an extra boost of concentrated exosomes on top. This approach can enhance the effectiveness of the treatment, as opposed to using a basic PRP alone. If you’ve previously had PRP treatments with Magellan or Angel, you’ll be glad to know Exosmart can integrate with these – you won’t be losing any of the advantages of those systems; rather, you’ll be amplifying them. Our clinic’s philosophy is to leverage the best technologies together, so you receive a comprehensive regenerative therapy for hair loss.
How Does Exosmart Compare to PRP Alone?
Exosmart’s autologous exosome therapy is essentially an evolution of PRP therapy, and it offers several key advantages over PRP alone for hair restoration:
- Higher Concentration of Healing Factors: By design, Exosmart delivers a far more concentrated dose of regenerative signals than standard PRP. In fact, the ultrafiltration process yields on the order of 10–50× higher extracellular vesicle (exosome) concentration compared to conventional PRP . Laboratory validation of Exosmart shows trillions of exosome particles per milliliter in the final product, whereas a normal PRP injection would contain only a fraction of that amount. Moreover, specific growth factors that promote hair growth (such as VEGF, PDGF, FGF2, and TGF-β) are found at significantly higher levels in the exosome concentrate than in regular PRP . This means each Exosmart treatment delivers a more potent “cargo” of hair-growth signals to your scalp.
- Enhanced Mechanism of Action: Standard PRP relies on platelets releasing growth factors after injection into the scalp. Exosmart takes it a step further by harvesting those growth factors in advance in the form of exosomes, and it even triggers the platelets to release extra vesicles during processing (through shear stress stimulation) . Essentially, Exosmart squeezes out every bit of regenerative potential from your platelets and concentrates it. The exosomes are also very small (around 50–150 nm) , which allows them to penetrate and be absorbed by cells more readily than whole platelets. This could translate to a more efficient stimulation of hair follicles once administered. In summary, Exosmart PRP is PRP “supercharged” – delivering a richer and more bioactive treatment to the hair roots.
- Results and Number of Treatments: Thanks to its higher potency, Exosmart may achieve noticeable results faster or with fewer sessions than traditional PRP. With standard PRP alone, we typically recommend a course of 3 initial treatments (one per month) for new patients, followed by a booster at 6 months, and then maintenance treatments roughly every 9 months . Patients often start seeing reduced shedding and some new growth after the second or third PRP session. In early experience with Exosmart, some patients have reported visible improvements (such as decreased hair fall and the appearance of new “baby hairs”) even after just 1–2 exosome treatments, which is very encouraging. While individual results vary, the enhanced therapy might mean you don’t need as many sessions to reach a similar or better level of improvement in hair thickness. We generally anticipate that an initial protocol of 2 Exosmart sessions spaced about a month apart can deliver significant benefits for most people.
- Maintenance Frequency: Because the exosome therapy effect can be more robust and long-lasting, maintenance treatments may be needed less frequently than with PRP alone. Many PRP patients opt for maintenance roughly yearly anyway, and with Exosmart it’s conceivable that a single booster once a year could be sufficient to sustain your results (some patients might even maintain results longer). By contrast, with standard PRP some clinicians recommend maintenance every 6–9 months . Of course, the ideal schedule will depend on your individual response – our team will monitor your progress and tailor a plan that keeps your hair improvement steady. The good news is that even if fewer sessions are needed, you are not missing out on anything; you’re in fact gaining a higher dose of the good stuff each time.
Overall, clinical case data and research suggest that adding Exosmart exosomes leads to greater hair regrowth than PRP alone, thanks to the amplified concentration of growth factors and regenerative vesicles. By delivering a powerhouse of healing signals directly to struggling follicles, Exosmart can potentially jump-start hair growth in a way that outperforms the standard PRP approach. This means a more efficient treatment journey for you – possibly achieving your hair goals with less time and fewer injections in the long run. We will keep you informed with honest expectations, and we’re excited that this advancement gives patients an edge in the fight against hair loss.
Can It Be Combined with Other Treatments like Minoxidil and Finasteride?
Yes, certainly. Exosmart exosome therapy can be used alongside other hair loss treatments such as minoxidil and finasteride, and we often recommend a combined approach for best results. There is no conflict or adverse interaction between exosome injections and these medications – in fact, they complement each other. Minoxidil (topical foam or solution, or low-dose oral tablets) works by increasing blood flow to hair follicles and prolonging the growth phase of hair, while Finasteride (Propecia™) for men works by reducing DHT hormone levels that cause follicle miniaturization. These address the hormonal and circulatory aspects of hair loss. Meanwhile, exosomes address the regenerative and restorative aspect, directly encouraging follicle recovery and new growth. Using them together means you are tackling hair loss on multiple fronts.
At Rejuvence, our hair loss treatment plans often incorporate conventional therapies in parallel with regenerative ones. For example, you might continue using your minoxidil and finasteride as prescribed while undergoing monthly PRP or exosome sessions – this is a strategy we frequently employ and find very effective . The exosome treatment will not interfere with your daily medication routine. If anything, improving the health of your scalp with exosomes can make it more receptive to topical treatments like minoxidil (better absorption) and can preserve follicles so that finasteride has more hair to protect. We also advise on other supportive measures – such as nutritional supplements (e.g. vitamin D, biotin, amino acids), low-level laser therapy, and lifestyle factors – which can all work synergistically. Rest assured, you won’t have to choose one or the other; exosome therapy is an add-on that boosts the overall effectiveness of your hair loss regimen. Our doctors will guide you on how to integrate all these treatments safely. The goal is to give you the best possible outcome by combining proven therapies: the strength of medical science (medications) with the cutting-edge of regenerative medicine (Exosmart).
What Is the Scientific Evidence Behind Exosmart, and How Does It Compare to Plant or Animal-Derived Exosomes?
Exosmart’s technology is grounded in solid scientific evidence and quality standards. The system was developed in line with the latest international guidelines for exosome research (MISEV 2023) and has undergone independent validation in the lab . Scientific testing has confirmed that the vesicles isolated by Exosmart are genuine platelet exosomes: they carry the characteristic exosomal markers CD9, CD63, CD81 (these are proteins on exosome surfaces used by scientists to identify them) . The particle size range and morphology have also been verified to match those of exosomes, and the purity is very high – with minimal cellular debris or contaminants in the final product . This means you’re getting a clean, highly concentrated exosome therapy that meets rigorous quality criteria. In fact, Exosmart is CE-MDR certified as a Class IIa medical device , indicating it complies with strict EU/UK medical device regulations for safety and efficacy. Few if any exosome products on the market have this level of regulatory approval for clinical use. This should give you peace of mind that the treatment is produced under high standards and is safe for patients.
Beyond the technical validation, a growing body of research supports the therapeutic benefits of platelet-derived exosomes. Studies have shown these exosomes can stimulate tissue regeneration in various fields: for example, accelerating wound healing in chronic ulcers , improving joint healing in osteoarthritis, and even aiding in cardiac and nerve repair. Specific to hair restoration, while large clinical trials are still forthcoming (as this is a very cutting-edge therapy), the underlying science is very promising. Platelet exosomes carry a host of growth factors (like VEGF, PDGF, IGF-1) that are known to be critical in hair follicle development and cycling. One independent analysis highlighted that platelet-derived exosomes have powerful effects on the scalp environment – they promote angiogenesis (new blood vessels) and modulate inflammation, which are key to reviving dormant follicles . Another noted that applying concentrated platelet exosomes led to activation of dormant hair follicles and improved hair density in observational cases . So, the scientific consensus is building that these autologous exosomes are an effective way to harness what made PRP successful, delivering it in a more potent form.
Compared to plant or animal-derived exosomes, autologous (your-own) exosomes have clear advantages. Some clinics or products advertise exosomes derived from sources like plants (e.g. corn stem cell exosomes or rice exosomes) or from animal cells, but these are fundamentally different from human platelet exosomes. Plant exosomes may have some biochemical effects, but they are not naturally intended to signal human hair follicles and there is very limited evidence that they can regrow hair. More importantly, exosomes from other organisms or donors come with safety uncertainties. With donor-derived exosomes (such as those taken from placental or neonatal tissues, which are not your own), there is a risk – however small – of immune reactions, disease transmission, or contamination, since you are introducing a foreign biological product. Regulatory bodies like the FDA have issued warnings about unapproved allogenic exosome products for exactly these reasons. By contrast, Exosmart uses your own blood with no external additives, eliminating those risks entirely . Autologous exosomes are inherently biocompatible and personalized to you. They also tend to be fresh and viable, as they are prepared on the spot and used immediately, rather than being processed, shipped, and stored for long periods like off-the-shelf exosome products. In short, scientific and clinical evidence favors autologous platelet exosomes as a safe and promising route for hair loss therapy, and Exosmart is at the forefront of delivering that therapy in a controlled, certified way. You can feel confident that this treatment is backed by both cutting-edge science and stringent quality control.
Rejuvence Clinic – First in the UK with CE-Certified Exosmart, Combined with Advanced PRP
Rejuvence Clinic is proud to be the first clinic in the UK to offer the Exosmart™ autologous exosome treatment for hair loss. This means our patients get early access to a revolutionary therapy that is CE-MDR certified and meets the highest safety standards in Europe . We have extensive experience in Platelet Rich Plasma treatments – as a recognized centre of excellence for PRP, we already provide Level II Magellan TruPRP™ and Level III Angel Arthrex™ systems to achieve superior PRP results . Now, by incorporating Exosmart, we can take your hair restoration to the next level. Our clinic’s Level II and III PRP protocols integrate seamlessly with the Exosmart process, meaning we can combine advanced PRP and exosomes in one comprehensive treatment plan. This multi-faceted approach is unique to Rejuvence Clinic and is designed to maximize hair regrowth while maintaining safety and comfort.
Being the first in the country with this treatment, we understand that patients may have questions or curiosity about it – and we are here to guide you through every step. Our medical team has undergone specialized training with the Exosmart system and remains up-to-date with the latest research in regenerative medicine. We emphasize clear, honest communication and patient education, so you can make an informed decision about trying this therapy. If you’re considering advanced hair loss treatments because traditional methods haven’t given you the results you want, Exosmart autologous exosome therapy could be a game-changer. It offers a natural yet powerful solution, leveraging your body’s own healing abilities to revive your hair. And with Rejuvence Clinic’s track record of innovation and patient-focused care, you’ll be in the best hands to experience this new treatment.
In summary, Exosmart autologous exosome therapy is an exciting advancement for treating androgenetic alopecia in both men and women. It helps hair follicles by providing concentrated growth signals straight from your own blood, it can be safely combined with other therapies, and it’s backed by scientific validation and regulatory approval. Rejuvence Clinic is delighted to lead the way in the UK, offering this therapy as part of our commitment to cutting-edge, safe, and effective hair loss solutions. If you’re looking for a friendly, expert team to help you explore regenerative hair restoration, we’re here for you – and we’re thrilled to bring you the latest innovation to support your hair growth journey. Here’s to thicker, healthier hair with the help of your very own cells!
Sources:
- Rejuvence Clinic – PRP Treatment for Hair Loss (Advanced PRP systems and treatment protocol)
- Exosmart™ Technical Brochure – Ultrafiltration Isolation of Platelet Exosomes (Process and yield details)
- Exosmart™ Scientific Presentation – Validation & Advantages (EV concentration vs PRP, processing time, safety)
- Exosmart™ Clinical Applications – Hair Restoration (Mechanism for stimulating follicles and angiogenesis)
- HansaBioMed Life Sciences – Press Release 2024 (Regenerative effects of platelet-derived exosomes on follicles)
- Rejuvence Clinic – Hair Loss Treatments Overview (Use of minoxidil, finasteride, and multi-therapy approach)
- Exosmart™ Flyer – Key Features (Autologous safety, no donor risks, 30–40% increased exosome release)
Exosmart™ Validation Data – Growth Factor Levels & Marker Analysis (Higher VEGF/PDGF in exosome product vs PRP; exosome markers confirmed)