Polynucleotides
‘Treatment is tailored, evidence-based and designed to enhance your skin’s natural regenerative potential.’
POLYNUCLEOTIDE TREATMENTS IN LONDON
Next-Generation Skin & Under-Eye Regeneration — Doctor Led at Rejuvence Clinic
At Rejuvence Clinic, we deliver advanced polynucleotide treatments designed to restore skin health, improve collagen quality and rejuvenate delicate areas such as the under-eyes—without adding artificial volume. This is regenerative aesthetics at its most refined: subtle, biological and medically precise.
As a CQC-registered clinic, all treatments are prescribed and delivered by experienced doctors and supported by a multidisciplinary team specialising in dermatology, lasers and regenerative medicine. Our focus is long-term skin quality, not short-term cosmetic fixes.
PREMIUM & TRUST SIGNAL
Natural Regeneration. Medical Precision. Trusted Results.
Polynucleotides at Rejuvence Clinic are delivered in a luxury medical environment where advanced science meets meticulous aesthetic care.
REGENERATION & UNDER-EYE REJUVENATION AT REJUVENCE CLINIC
Modern aesthetic medicine is moving away from over-filling and artificial correction towards biological regeneration. Polynucleotides sit at the centre of this shift. They improve skin quality from within, strengthening tissue, supporting collagen production and restoring vitality – particularly in fragile areas such as the under-eyes.
At Rejuvence Clinic, polynucleotides are a core part of our regenerative aesthetic offering, frequently combined with advanced energy-based devices to deliver refined, natural and progressive results.
What Are POLYNUCLEOTIDES?
Polynucleotides are highly purified DNA fragments designed to be fully biocompatible with human tissue. Once introduced into the skin, they act as powerful cellular messengers that support tissue repair, hydration and regeneration at a deep biological level.
Rather than altering facial shape or adding volume, polynucleotides work by:
- Stimulating neocollagenesis (new collagen formation)
- Improving skin thickness, elasticity and resilience
- Enhancing hydration and tissue quality
- Reducing inflammation and oxidative stress
This makes them ideal for patients seeking natural rejuvenation and skin strengthening rather than structural change.
UNDER-EYE Rejuvenation With Polynucleotides
Polynucleotides + Aerolase Neo for Dark Circles & Skin Quality
The under-eye area is one of the most technically demanding regions to treat safely. Polynucleotides are particularly well suited to this area as they improve skin quality without adding bulk, making them ideal for thin, crepey or fragile under-eye skin.
At Rejuvence Clinic, we frequently combine polynucleotide injections with Aerolase Neo laser treatment to achieve superior under-eye rejuvenation. Polynucleotides strengthen the dermis, improve collagen content and enhance hydration, while Aerolase Neo targets pigmentation, vascular congestion and collagen stimulation using gentle, non-ablative laser technology that is safe for all skin types.
As a paired approach, this combination can:
- Improve under-eye skin texture and thickness
- Support collagen regeneration
- Reduce dark circles related to pigmentation
- Brighten the under-eye area naturally
- Deliver progressive improvement without heaviness or downtime
For more information on Aerolase Neo for dark circles, please visit:
Aerolase Neo for Dark Circles
Global Facial & Peri-Orbital Rejuvenation
Beyond the under-eyes, polynucleotides are used across the face to improve overall skin health, elasticity and resilience. They are particularly effective for early ageing, dullness, dehydration and skin fragility.
They are also well suited to delicate areas such as the eyelids, temples, neck and décolletage, where traditional volumising treatments may be inappropriate. Treatments are always prescribed and delivered by doctors following a detailed medical assessment.
Polynucleotides & Scar Regeneration
Polynucleotides play an important role in scar repair and skin remodelling. At Rejuvence Clinic, they are commonly used as part of structured scar treatment pathways.
They may be used:
- Post-operatively to support optimal healing
- After laser or surgical scar revision
- To promote neocollagenesis in atrophic scars
- Following steroid treatment of hypertrophic or keloid scars to improve skin texture and quality
By supporting healthier collagen organisation and reducing inflammation, polynucleotides help scars heal more evenly and with better long-term cosmetic outcomes.
Combining Polynucleotides with Advanced Technologies
Polynucleotides are rarely used in isolation at Rejuvence Clinic. Their strength lies in how well they integrate with advanced technologies.
Aerolase Neo is commonly paired with polynucleotides to address redness, pigmentation and inflammation while stimulating collagen safely across all skin types.
BBL Sciton may be added when vascular redness or pigmentation is a key concern, particularly in lighter skin types, with polynucleotides supporting recovery and skin regeneration.
Sylfirm X radiofrequency microneedling combines exceptionally well with polynucleotides for improving skin texture, under-eye crepiness, fine lines and atrophic scarring. Sylfirm X stimulates controlled collagen production while polynucleotides optimise tissue repair.
Polynucleotides VS Other Injectable Treatments
Polynucleotides differ fundamentally from many other injectable treatments.
Dermal fillers (such as hyaluronic acid or PCL-based products) are designed to add volume or structural support and are not always suitable for delicate areas like the under-eyes.
Bio-remodelling injectables such as Profhilo focus primarily on hydration and mild collagen stimulation but do not offer the same level of cellular repair and tissue regeneration.
Polynucleotides focus on:
- Skin regeneration rather than volume
- Long-term collagen quality
- Improved tissue resilience
- Safe use in fragile or high-risk areas
Selection of treatment at Rejuvence Clinic is always anatomy-led and goal-driven.
MEET THE DOCTORS
Dr Sam Ghani leads the aesthetic and regenerative medicine services at Rejuvence Clinic. He was among the first clinicians in the UK to complete the Master’s degree in Aesthetic Medicine at Queen Mary University of London, reflecting his early commitment to academic excellence and advanced clinical practice.
Dr Ghani specialises in advanced tear trough treatment, with particular expertise in both thermal fillers and polynucleotide-based regeneration, allowing treatments to be precisely tailored to anatomy, skin quality and long-term outcomes. His work focuses on natural results achieved through the most current injectables, regenerative techniques and energy-based technologies.
Your Consultation At Rejuvence
Every treatment begins with a detailed medical consultation. We assess skin quality, under-eye anatomy or scar history and discuss whether polynucleotides alone or in combination with lasers or RF microneedling will deliver the best outcome.
This ensures safe, personalised and effective treatment planning.
Book Your Consultation
If you are seeking natural under-eye rejuvenation, advanced skin regeneration or improved scar quality delivered in a medically led environment, polynucleotide treatment at Rejuvence Clinic offers a sophisticated, evidence-based solution.
You can book online or explore your options through our website chatbot.
