Tendons, Joints & Muscles PRP London, UK
“Regenerate. Restore. Rise Again.”
“Regenerate. Restore. Rise Again.”
Cutting-edge PRP and autologous exosome therapy for your joints and sports injuries—at the UK’s leading regenerative clinic.
Cutting-edge PRP and autologous exosome therapy for your joints and sports injuries—at the UK’s leading regenerative clinic.
Why Choose Rejuvence Clinic for Advanced PRP and Exosome Therapy in London?
At Rejuvence Clinic, we lead the way in regenerative orthopaedic medicine, providing advanced Platelet-Rich Plasma (PRP) and autologous exosome (ExoSmart™) treatments for joint pain, ligament and tendon injuries, and muscle recovery.
Our treatments target multiple musculoskeletal areas — including knees, hips, shoulders, and elbows — and can address several regions safely in the same session.
All injections are performed under ultrasound guidance by a senior Orthopaedic Surgeon, ensuring precise delivery and optimal results.
What Makes the Angel Arthrex System the Gold Standard for PRP?
The Angel Arthrex System delivers the most refined and consistent PRP available. Unlike basic single-spin centrifuges, it allows full customisation of cellular composition, including red and white cell control, to tailor anti-inflammatory or regenerative properties to your specific condition.
Key clinical advantages:
- Up to 18× platelet concentration versus standard PRP systems.
- Large-volume output (up to 12 mL), ideal for multi-site treatments.
- Customisable leukocyte profiles for arthritis vs tendon repair.
- Closed sterile design maintaining platelet viability and preventing contamination.
The Angel Arthrex platform is used in Royal London Hospital and leading orthopaedic centres in the UK and US, with a strong research track record in cartilage regeneration and tendinopathy recovery.
How Does ExoSmart™ Take PRP Therapy to the Next Level?
The ExoSmart™ Autologous Exosome Concentration System refines your PRP further by extracting exosomes — microscopic vesicles that drive cellular regeneration. These platelet-derived exosomes contain growth factors, cytokines, and micro-RNAs that promote repair, reduce inflammation, and stimulate tissue renewal .
Together, Angel Arthrex PRP and ExoSmart™ exosomes deliver a biological combination unmatched in concentration and precision for joint and soft tissue healing.
What Sets ExoSmart™ Apart Scientifically and Technologically?
Through precision ultrafiltration (15 kDa membrane, ~5 nm pores), ExoSmart™ separates and concentrates regenerative vesicles while filtering out plasma water and unwanted proteins.
Scientific validation:
- 10–50× higher exosome yield than standard PRP .
- Trillions of exosomes per millilitre (up to 3×10¹³/mL) with <1% contamination .
- Shear stress activation induces 30–40% more vesicle release .
- 5× plasma concentration efficiency, all in under 30 minutes.
- Fully CE-MDR and ISO 13485 certified with MISEV2023 compliance and independent lab validation (Hansabiomed, MEDICA).
The result: a biologically potent, autologous exosome concentrate optimised for orthopaedic, sports and soft tissue regeneration.
What Does the Current Evidence Say for Common Musculoskeletal Conditions — and How Does the Science Work?
At Rejuvence Clinic, we use PRP and autologous exosome therapy to manage a variety of musculoskeletal (MSK) conditions, often treating multiple areas in one session. Commonly treated regions include the knees, hips, shoulders, and elbows, though applications extend to tendons, ligaments, and muscle injuries across the body.
What Does the Current Evidence Say for Common Musculoskeletal Conditions — and How Does the Science Work?
The synergy of Angel Arthrex PRP and ExoSmart™ exosomes is grounded in validated molecular biology. ExoSmart™ isolates platelet-derived extracellular vesicles (EVs) — nanosized “messenger” particles rich in PDGF, VEGF, TGF-β, FGF, and anti-inflammatory cytokines (IL-10, IL-1RA) .
Using a 15 kDa ultrafiltration process, ExoSmart™ achieves 5× concentration, enhances exosome yield by 30–40% through shear stress activation, and ensures vesicle purity (<1% contamination) .
Independent analyses confirm up to 3×10¹³ particles/mL, validated through NTA, TEM, and flow cytometry.
PRP and exosomes reduce pain and improve function in degenerative knee conditions. The growth factor-rich exosome fraction stimulates cartilage matrix repair and reduces inflammation. Clinical data suggest benefits in pain reduction, mobility, and joint preservation.
Autologous exosome therapy aids cartilage protection and tendon healing in hip conditions, supporting fibroblast activation and angiogenesis for long-term recovery. CE-MDR validation includes hip and musculoskeletal applications.
PRP and exosomes accelerate healing in rotator cuff injuries, stimulating tenocyte proliferation and collagen remodelling while moderating inflammation. Verified CD9/CD63/CD81 expression confirms active, intact exosomes.
Autologous PRP with ExoSmart™ provides consistent biological potency (CV < 20%) for chronic tendon pain. It promotes collagen alignment, pain reduction, and improved grip strength
Because the therapy is entirely autologous and biocompatible, it can be administered to more than one area in a single visit — such as both knees, or a shoulder and elbow combination. This flexibility benefits active individuals and athletes with multi-joint wear or overuse syndromes.
Every injection at Rejuvence Clinic is ultrasound-guided and surgeon-delivered, ensuring precision placement into cartilage layers, tendon sheaths, or soft tissue planes for optimal regeneration.
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Why Are Autologous Exosomes Safer Than Synthetic Alternatives?
Rejuvence Clinic exclusively uses autologous exosomes derived from your own blood — eliminating risks associated with donor, plant, or placental products.
Synthetic or imported exosomes are not licensed for use in UK joint injections and have been linked to CQC and MHRA sanctions on non-compliant providers.
Our approach adheres to the highest safety, ethical, and regulatory standards, ensuring effective, evidence-led care.
Can PRP or Exosome Therapy Be Combined with Hyaluronic Acid?
Yes — and it’s often the most effective approach for osteoarthritis and cartilage wear.
Rejuvence Clinic is an authorised centre for Ostenil Plus, a premium hyaluronic acid injection that improves joint lubrication, shock absorption, and hydration. When staged with PRP or exosomes, it enhances comfort and prolongs joint protection.
Are PRP and Exosome Therapies Regulated and Evidence-Based?
Absolutely. Both Angel Arthrex and ExoSmart™ are CE-MDR Class IIa medical devices, manufactured under ISO 13485 / ISO 14971 and validated in independent laboratory studies.
They meet international MISEV2023 standards and are supported by 200+ peer-reviewed publications across orthopaedics, wound healing, and sports medicine.
Why Is Rejuvence Clinic the Leading PRP & Exosome Centre in London?
- Led by a senior Orthopaedic Surgeon experienced in guided regenerative procedures.
- Exclusive use of Angel Arthrex and ExoSmart™ systems — used in leading UK hospitals.
- Compliant, ethical, and scientifically verified treatments.
- Personalised care plans addressing single or multiple MSK sites.
The results of degenerative joint treatments would be expected to become evident approximately 6 weeks after the initial treatment and if needed treatments can be repeated. Of course individuals will vary in their response to treatment and this is especially dependent upon lifestyle choices including smoking and alcohol consumption. In the case of soft tissue sports injuries, the effects are likely to be noticed sooner with accelerated regeneration and return to sporting activities.
For further details please book a consultation.
