PRP & Exosome Hair Treatment London, UK
At Rejuvence Clinic we are able to offer the most advanced Platelet Rich Plasma hair treatments in London for male and female pattern hair loss as well as steroid resistant alopecia areata. We are able to tailor bespoke treatment plans for our clients.
To maximise results we can combine oral and topical treatments such as Replenology™ Vitamin Supplements, Minoxidil or Finasteride with regenerative medicine techniques such as advanced PRP from Magellan™ and Angel Arthrex™, nanofat and have recently introduced the use of E50™ Exosomes and copper peptide based PEP Factor™.
Hair loss is becoming more common!
Unwanted hair loss is an extremely common and often very distressing problem affecting both men and women. By the age of 60, most men and women will suffer from some form of hair thinning. However, in a significant number early onset male and female pattern hair loss can be the cause of significant psychological distress. A normal head of hair consists of between 100,000 to 120,000 hairs. On average most people lose 60 hairs per day. This is a normal part of the hair cycle. However, for those suffering with pattern or Androgenic hair loss this number is much larger. By the time one can see through to the scalp they have often lost over 50% of their original hair in that region. During the pandemic there was a significant spike in Alopecia Areata following infection with Covid-19. Due to the lock down many were unable to obtain fast and effective treatment. As a result many developed chronic alopecia areata. |
What treatments are available at Rejuvence for hair loss?
There are a large number of treatment options for hair loss for both males and females. Treatments and their success depend upon the underlying cause of hair loss. The most common type of hair loss in both men and women is Androgenic (‘Pattern’) Hair Loss. Established first line treatments include Minoxidil Foam or Gel, Caffeine based shampoos, Finasteride (Propecia™) for men as well as Low Level Laser Therapy. We normally recommend vitamin supplementation with our Replenology range. In addition we regularly use Minoxidil tablets, Finasteride and Spirinolactone. All of these treatments can help to reduce hair loss to some extent. For more extensive hair loss and balding many men and women consider a FUE hair transplant but this should really be considered the last option. At Rejuvence our resident hair transplant specialist Dr Waqas Chaudhary offers FUE Hair Transplants.
Platelet Rich Plasma (PRP) has emerged over the last 5 years as a very promising treatment for hair loss with many patients showing significant reduction in hair loss, and even significant increases in new hair growth. However, the effectiveness of Platelet Rich Plasma (PRP) is specifically dependent upon platelet concentration, platelet viability and purity of PRP samples obtained. Exosomes are small packets of proteins and growth factors that are produced and released by almost all cells. Scientists are now able to grow exosomes in the lab and store them for use in the treatment of hair loss. When combined with microneedling theyare absorbed by cells of the scalp easily and can trigger regeneration and growth of hair follicles.
How is Platelet Rich Plasma performed?
Rejuvence Clinic is a centre of excellence for Platelet Rich Plasma. We offer a three tiered PRP service. Our Level I service is our entry level PRP – Neogenesis PRP. We are authorised providers for Magellan TruPRP™ (Level II) and Angel Arthrex™ PRP (Level III) systems. Our Advanced Platelet Rich Plasma (PRP) Treatments for hair loss are non-invasive procedures.PRP is a completely natural treatment and produced using your own blood. Blood is taken and subsequently run through a machine known as a centrifuge. The centrifuge separates the blood into its different cellular components. Once finished, centrifugation will split your blood samples into different layers of cells and the platelet rich plasma layer is extracted using a syringe manually. Our Level I Neogenesis System uses a swing out centrifuge set-up and produces PRP in this manner.
The Angel Arthrex™ and Magellan TruPRP™ systems are based around very advanced centrifuges that are completely automated and able to identify the platelets in your blood, concentrate and extract them. Both Angel and Magellan are able to produce very high concentrations of PRP needed for effective treatment of hair loss especially male and female pattern hair loss.
Once the PRP is ready this is injected into the affected areas of the scalp using an automated injector device. At Rejuvence Clinic we recommend a series of 3 treatments over 3 months for all patients new to PRP followed by a further treatment at 6 months and then maintenance treatments every 9 months. This is all based on data and research published in prominent medical journals.
Not all PRP is the same. How is Rejuvence different to other clinics?
PRP is widely available in clinics across the UK. However, there is a large variation in the cost of treatments. It is important to understand that not all PRP is the same. For PRP to be effective it is generally agreed that the concentration of platelets needs to be at least 4 to 5 times higher than in blood. The majority of PRP systems used in clinics across the UK claim to achieve this concentration but that is simply not true. At best test tube centrifugation systems used by the majority of clinics can achieve only 2-3 times concentration.
©Individual results may vary
Three Tiered PRP Hair Loss Treatments for everyone!
We consider ourselves a centre of excellence for PRP. Hence we have taken great care and effort to ensure we use only the best systems in our clinic to ensure we deliver high quality PRP to all our clients. We have a three tiered PRP service at Rejuvence Clinic.
For all our hair loss clients we always recommend a comprehensive trichoscopic assessment of the scalp. This is a photographic assessment of your hair follicles and using AI technology we are able to provide a detailed report of the number, thickness and density of your hair. By repeating this assessment at 6 months and a year after treatment we can assess the objective progress of your hair and how much it has improved thanks to TrichoLAB.
Level I
Our entry level PRP system is the Neogenesis PRP system. This is a more conventional PRP system and involves collecting 30ml of blood to produce 2-4ml of PRP with a concentration in the range of 2-3 times. This is effective for mild to moderate hair loss for those on a budget. It uses a swing out centrifuge and a single spin cycle. Our Level I PRP treatment is still better than most thanks to a superior centrifuge and larger volume syringes. However, we do recommend Magellan TruPRP and Angel Arthrex for those looking for the best outcome.
Level II
The Magellan TruPRP system is a very high end PRP system. It involves blood draw of between 60 and 120ml of blood. It yields 6-12 ml of high concentration PRP with platelets counts in the region of 4-5 times higher than baseline. The Magellan TruPRP system use a specialised centrifuge that runs a 2 spin protocol incorporating a hard and a soft spin. The machine is fully automated with density scanning. Magellan TruPRP is especially suitable for hair loss in those with androgenic alopecia and also for those who have had a hair transplant. All Level II PRP treatments for hair loss require a consultation with one of our doctors beforehand. To book your consultation now click the Book Now link below.
Level III
The Angel Arthrex System is our gold standard PRP unit. This Involves a blood draw of between 60 and 180ML. It can yield between 6 to 18ml of high concentration PRP with platelet counts in the region of 4-5 times higher than baseline. The Angel Arthrex system uses a specialised centrifuge that runs a two spin program similar to Magellan TruPRP. The Angel system also incorporates a density scanning function ensuring consistent and automated PRP production. The difference between Angel Arthrex and Magellan TruPRP is that the Angel system allows for customisation of the specific cellular constituents of the PRP as well as larger volume of PRP. This allows for bespoke PRP which is especially important for the treatment of certain conditions such as alopecia areata. Angel Arthrex is used for the treatment of all types of hair loss. If you are looking for the best PRP we always recommend Angel Arthrex. All Level III PRP treatments for hair loss require a consultation with one of our doctors beforehand. To book your consultation now click the Book Now link below.
How does PRP help with Hair Loss?
Over the last few years there has a been huge interest in the potential of platelet rich plasma to treat hair loss. The combination of micro needling and platelet rich plasma has been shown recently to significantly increase hair thickness, hair count and thereby hair density. PRP works by acting as a chemical messenger once activated and injected. It attracts growth factors and stem cells that have a direct effect on the bulge cells of the hair follicles. Growth factors and stem cells also have ‘angiogenic’ properties. This means they stimulate the development of new blood vessels in the scalp which also helps fight hair loss.
Studies over the last five years have demonstrated approximately 20% increase in hair thickness following on average 3 sessions over 3 months with maintenance sessions every 9 to 12 months. PRP tends to be more effective when started early before large bald patches appear. However, not all clinics are able to achieve similar results. This is because not all PRP is the same. PRP is only effective if the concentration of platelets achieved is greater than 4 to 5 times baseline levels.
The majority of clinics offering PRP use preparation methods that can only achieve concentrations 2 to 3 times greater than baseline. At Rejuvence Clinic we use Angel Arthrex™ and Magellan TruPRP™. This system is guaranteed to yield PRP with a concentration of platelets greater than 5 times baseline and hence our treatments tend to perform much better than other clinics (although individual results may vary). In addition the Angel Arthrex system allows for complete customisation of the cellular contents of PRP by being able to adjust the percentage of red cells. The presence of red cells in the final PRP serum is especially significant in the treatment of severe and recurrent forms of Alopecia Areata not responding to steroids.
PRP treatment following a FUE Hair Transplant
Platelet Rich Plasma is increasingly being used by hair transplant surgeons during surgery. Most transplant surgeons including our resident surgeon, Dr Waqas Chaudhary, recommends all patients have a course of PRP 3 to 4 months following their hair transplants.
PRP has angiogenic properties. This means PRP helps improve the blood supply in areas where it is injected and this is extremely important for newly transplanted grafts. Following a FUE Hair Transplant, a course of 3 PRP sessions can help to secure and strengthen transplanted hairs and ensure they thrive. PRP treatments on a regular basis can also help to improve hair over the rest of the scalp. Many forget that androgenic (‘pattern’) hair loss does not stop and cannot be cured. Hence regular maintenance treatments are still needed. PRP is also helpful where a transplant has not worked as well as it should and can thicken and strengthen grafts, even years afterwards.
At Rejuvence, using Angel Arthrex™ and the Magellan TruPRP™ systems we have achieved really great results for patients who have come to us following a FUE transplant. We have even treated patients who have had their transplant years ago and have been left disappointed with the results. PRP has helped to thicken thin ‘wispy’ grafts. For the best PRP nourishment for your FUE transplant book an appointment with us.
Exosomes for hair loss - What are exosomes?
Exosomes are a new break through treatment alternative for hair loss. Exosomes are produced by almost all cells in the body. They are essentially small packets released by cells containing a variety of proteins, growth factors, specific genetic material called RNA and mRNA as well as signalling molecules. These packets have a ‘lipid bilayer’ wall and are extremely small. This means they are easily absorbed by surrounding cells and able to easily deliver their contents. Cells of particular organs produce specific types of exosomes. Exosomes are capable of promoting tissue regeneration, new blood vessel development as well as having anti-inflammatory properties. When specific types of exosomes are delivered to the scalp they can initiate new hair growth.
Where do Exosomes come from?
Exosomes are generally obtained from three main sources. They can be derived from plants, animals or humans. Ideally, the science suggests that the most effective exosomes are likely to be derived from humans and specifically from stem cells in the umbilical cord or mesenchymal stem cells. These stem cells have the greatest ability to remodel into any other cell and hence likely to produce exosomes that are the most versatile. At present there are a number of groups in South Korea and the United States that have successfully mass produced human derived exosomes from mesenchymal stem cells and are trialing these in a multitude of medical conditions. However, all human derived products including exosomes are banned in the UK and Europe and hence not available. Plant derived exosomes and animal derived exosome products are available on the market and are approved for use in the UK. They have also been shown to be effective in a variety of conditions including hair loss.
E50 Exosome with Sylfirm X at Rejuvence
E50™ Exosomes are derived from salmon testes. Salmon testes are known for their purified DNA and are an excellent source for exosomes safe for human use. E50 exosomes are specifically engineered to contain growth factors and proteins that are able to help with androgenic alopecia. Specifically E50 Exosomes have a number of effects oh hair including the promotion and differentiation of hair follicle stem cells in the bulge cells of the hair follicle as well as the dermal papilla and outer root sheath. E50 also helps to reduce the telogen (resting) phase of the hair cycle and extend the anagen (growing) phase of the hair cycle thereby partially reversing the miniaturisation effects of male and female pattern hair loss. E50 exosomes also have a positive impact on the extracellular environment of the hair follicles improving conditions for hair growth as well as having potentially anti-inflammatory effects.
The treatment is carried out in conjunction with Sylfirm X – Radio Frequency Microneedling. Initially the scalp is treated with the Sylfirm X microneedling device and the E50 exosome is subsequently massaged into the scalp or better yet forced through the superficial layers of the skin using a spray gun called Target Cool. Radio Frequency Microneedling encourages new blood vessel development – angiogenesis – as well as initiate an inflammatory reaction yielding a growth factor and stem cell release that can stimulate miniaturising hair follicles.
The application of E50 can be combined with PRP or as a standalone treatment. When used as a standalone treatment it is recommended that the treatment be repeated 5 times at 1 month intervals followed by maintenance treatments twice a year.
At Rejuvence we are excited by the potential of this treatment especially in conjunction with both Magellan and Angel Arthrex PRP. Book a consultation now by calling 02075316600 or contacting us on WhatsApp.
PEP Factor Scalp
PEPFactor™ Scalp is a mesotherapy product developed by ReGen Factor – Australia. It is enriched with copper peptide, antioxidants and specifically bio-identical Fibroblast Growth Factor (FGF). Pepfactor promotes natural hair regrowth by stimulating collagen, skin and scalp regeneration alongside hair follicle regeneration.
Fibroblast Growth Factors (FGFs) promote hair growth by triggering the anagen (growth) phase in resting hair follicles. Topical administration of fibroblast growth factors encourages an earlier anagen phase and subsequently prolongs the growing phase in the hair cycle – the same mechanism by which the majority of non-surgical hair loss treatments work.
Copper peptides are a naturally occurring copper complex and more recently has become a key ingredient of some high-end anti-ageing skin care products. It supports the production of collagen and elastin and helps with repair of damaged tissue alongside antioxidant qualities. In the case of hair loss, copper peptides can stimulate the activity of hair follicles by again prolonging the anagen phase and accelerating the transition out of telogen (resting) phase.
What can PEPFactor Scalp do for my hair?
The key to success with PEPFactor™ is the unique combination of copper peptides and basic fibroblast growth factor. Together they can stimulate hair growth by prolonging the anagen phase of hair growth and promote cell proliferation and tissue repair. The combination of copper peptides and basic fibroblast growth factor contribute to healing and repair of the scalp – this can be a key factor in certain scalp conditions including psoriasis that can also be associated with significant shedding and subsequent hair loss. Both promote angiogenesis – the formation of new blood vessels. It is generally accepted that a reduction in scalp blood supply likely contributes to the development of male and female pattern hair loss. Finally copper peptides in tandem with fibroblast growth factor have antioxidant and anti-inflammatory effects – qualities that lend well to potentially benefiting certain scalp conditions such as CCCA (Central Centrifugal Cicatricial Alopecia). Its potential effects in Alopecia Areata are unclear but may benefit where other tried and tested treatments have failed.
PEPFactor at Rejuvence
At Rejuvence Clinic we are able to offer PEPFactor Scalp as a treatment in combination with one of our PRP systems or as a stand-alone treatment option. We normally recommend incorporating at least one session of PRP with PEPFactor Scalp and have seen significant improvements in hair regrowth. We also recommend incorporating it with our maintenance PRP protocols. PEPFactor is administered topically onto the scalp following injection of PRP and thorough scalp microneedling. PEPFactor is approved for use in the UK as a Cosmetic Product for topical application with microneedling/dermaroller. Hair Loss treatment success is dependent upon using a combination of treatment approaches to tackle a multi-factorial problem.
For further details on the use of PEPFactor in combination with PRP or as a standalone treatment for hair loss call us now on 02075316600 or WhatsApp us.
Stem cell treatments for hair loss
At Rejuvence we strive to push the boundaries providing cutting edge regenerative treatments yielding superior results. At Rejuvence we are introducing personalised cellular therapies for hair loss. This involves combining stem cells from your own fat with PRP to augment hair regrowth. Harvested fat is micronised (filtered) to produce a homogenised fat serum consisting of equally sized fat cells with large concentrations of stem cells and growth factors. This can easily be injected into the scalp and together with PRP has been shown to improve on responses from PRP alone. Using ACP Arthrex fat harvesting and Angel Arthrex PRP we are able to provide cutting edge scalp regenerative treatments.
REPLENOLOGY Hair - Replenishment & Nourishment
REPLENOLOGY Hair is a four part natural system formulated for use by both women and men to fully replenish nutrients that are lacking when experiencing hair loss and that are necessary for healthy hair. These nutrients target 21 causes of hair loss and support normal scalp & intrinsic hair functions along with providing cosmetic benefit to protect and improve the look of healthy and fuller hair. The Replenology Hair Daily Dietary Supplement can be combined with Replenology Daily Shampoo and Daily Conditioner. In addition the Daily Advanced Follicle Nutriment is a topical product that can be applied to specific patches of hair loss in much the same way as topical Minoxidil.
Replenology Hair works by replenishing nutrients in the hair follicles that have been depleted due to ageing, diet, hormonal changes, environmental effects, certain medication and long term exposure to chemical ingredients in some hair products.
What are the benefits of Replenology?
Replenology Hair has been formulated to target 21 known causes of hair loss and shown to replenish nutrients in the hair follicles that are not normally found in a regular diet and hair care products, including natural stilbenes, wedelolactones, procyanidins. Replenology Hair is not a drug with associated potential side effects.
When will I see results? Replenology Hair begins working for you on the 1st day of use and you may see results as early as 4 to 8 weeks after commencing daily use. However, it may take 4 to 6 months to notice an effect. This will depend on how depleted the nutrients are in each individual and other overall health factors. You may notice a reduction in hair fall within 4 to 8 weeks followed by fuller and healthier looking hair on the scalp within 4 to 6 months. Once you begin using the Replenology Hair four part system you may experience an improvement in your wellbeing and energy levels due to the multiple vitamins, minerals and botanicals, that are rich in nutrients, amino acids and antioxidants, found in each of the Replenology Hair products. An improvement in the overall condition of your scalp and hair may also be experienced due to the nourishment that Replenology Hair will provide for you. The gentle but powerful ingredients will also protect your hair against the effects of everyday pollution and ultraviolet exposure.
Does Replenology actually work?
Replenology is a novel botanical natural product treatment for male and female pattern hair loss. A recent multi-author study (systematic review and Bayesian network meta-analysis) comparing improvements in hair growth across the main non-surgical hair loss treatments for male and female pattern hair loss including minoxidil, Low Level Laser Therapy (LLLT), finasteride, dutasteride and Viviscal™. Replenology supplements demonstrated a statistically significant increase in terminal hair density in men and women that was greater than that observed for other treatment modalities included in the study. Women were found to have an accelerating terminal hair regrowth rate between 3 months and 6 months. Men had a continuous regrowth rate. Replenology did not demonstrate any signs of resistance whereas resistance was evident in all other treatment regimens. The study concluded that a multi-targeting treatment approach is required and that Replenology combined with PRP shows potential promise. However, statistical evidence of a superior response with Replenology compared to other more established non-surgical hair loss treatments does not mean it should completely replace minoxidil, finasteride or dutasteride.
At Rejuvence Clinic we stock Replenology products and specifically sell the Professional Grade Supplement. For further details on the Replenology product line and whether it could benefit you in your battle against hair loss call us on 0207 531 6600 or WhatsApp us.
The most common cause of hair loss in men and women is medically termed androgenic alopecia. It is otherwise known as male and female pattern hair loss. In men, this is usually due to effects of testosterone being converted to dihydrotestosterone by the enzyme 5-alpha reductase. Dihydrotestosterone results in a reduction in the blood supply to the scalp and gradual miniaturisation of hair follicles and lengthening of the hair cycle.
In women the cause of female pattern hair loss is not fully understood. Other common causes of hair loss include anaemia (normally due to iron deficiency), underactive thyroid and vitamin D deficiency. Other causes of hair loss can be due to stress and medication. Alopecia areata is an autoimmune condition where the body attacks it’s own hair follicles.
There are numerous treatments available at present for hair loss. Initial treatment is in the form of topical foams and shampoos, most well known of which is Minoxidil and must be applied to the scalp every night. Minoxidil usually takes about 9 months to take effect and can result on average in reduction of hair loss and about 1% increased hair growth. If stopped patients often suffer from a ‘rebound loss’ with increased hair fall. Caffeine based shampoos have also been touted as a treatment for hair loss. Numerous supplements are available over the counter and through prescription. These supplements replace vitamins and minerals that are potentially implicated in the cause of hair loss. Their success is limited. Prescription medications in the form of Finasteride have been shown to help and most patients awaiting a hair transplant are started on finasteride although this is not an option for women of childbearing age. Low level laser therapy has recently shown some promise in hair regrowth. Often once these treatments have failed patients jump to hair transplantation as the solution. This is not the answer in the majority of cases and is at best a camouflage solution. This is clear to see when you consider 3000 to 4000 grafts cannot make up for up to 60,000 hairs.
PRP has been gaining increased credibility over the last 5 years with more and more sceptical doctors being convinced of its positive effects on hair loss and in particular ‘pattern’ hair loss. The effects of PRP on hair loss are still, however, slightly variable. This is because it is a cellular based therapy dependent on a variety of factors that vary from patient to patient. However, most importantly there is a huge amount of variety in the quality of PRP treatments amongst clinics offering this treatment in the UK. Effects of PRP on hair loss can include up to 20% increased hair growth in affected areas around 6 months as well rapid reduction in hair fall. This is much more than can be achieved with just Minoxidil or Finasteride where new hair growth sits around the 1-2% mark at 9 months.
Our advanced PRP treatments at Rejuvence with the Angel Arthrex and Magellan TruPRP systems require a blood draw of 60ml or 120ml of blood depending upon the amount of PRP required. This is much more than used in other PRP setups at other clinics. This volume of blood being taken is completely safe and will not have any negative effects on you at all. We do always encourage patients to make sure they are well hydrated prior to attending clinic for their treatment.
For the treatment of male and female pattern hair loss we advise all our patients to treat the entire top of the scalp extending from the hair line to beyond the crown. In order to ensure thorough treatment we encourage patients to have the 12ml PRP treatment. The majority of other clinics are only able to generate 3-4ml of PRP that tends to be significantly lower concentration than we are able to produce with Angel Arthrex or Magellan TruPRP. In a single treatment of PRP at Rejuvence you will receive more PRP than in 3-4 treatments combined at other clinics.
We use an automated injector device called the U225 for injecting PRP into the scalp. The needles on the injector are very small and the pain involved is much less than if injected manually using a syringe. In addition the injector device allows us to precisely set the depth to which we inject the PRP and it is much quicker than doing it by hand. No anaesthetic is used. This is because local anaesthetic can have a negative impact on the effectiveness of PRP. The injection process is slightly uncomfortable but all our patients are able to easily tolerate the procedure.
There is no downtime associated with this procedure and patients can often return to work the following day. However, depending upon the amount of fat harvested from the flanks, there can be a bit of oozing that persists for 48 to 72 hours.
At Rejuvence we specialise in regenerative medicine techniques for hair restoration and believe with the advent of biocellular hair restoration using Angel Arthrex™ and Magellan TruPRP™ and micronised fat with stem cells and growth factors, fewer patients will have to opt for hair transplantation and more will successfully maintain their natural hairline for longer.
For further information please book a free consultation.
I-PRF is defined as Injectable Platelet Rich Fibrin. This is a second generation blood derived biomaterial in contrast to PRP which is a first generation platelet-based biomaterial. Fibrin is found in the blood and plays a specific role in clotting. The difference between platelet rich plasma (PRP) and injectable platelet rich fibrin (I – PRF) is the presence of a fibrin scaffold that means in I-PRF the effects of the platelets lasts for longer and there is longer sustained release of growth factors. However, overall PRP releases more growth factors but over a shorter period of time.
PRF has been used for some time in a gel form for the treatment of complex wounds and ulcers. Modifications to the preparation of PRP allows for the production of injectable PRF that is initially in a liquid form that turns to a gel after about 15mins. I-PRF has been found to help with hair loss following injection into the scalp in liquid form. As per best practice guidelines for PRP treatments for hair loss I-PRF is still in its infancy with no evidence that it is better than PRP. In addition, concentration of platelets is still most important for efficacy of treatment and I-PRF production protocols result in low concentrations.
At Rejuvence we are able to incorporate both PRP and I-PRF into treatment protocols especially for the treatment of hair loss in both men and women.
Regenera Activa has been coined as a stem cell treatment. It involves taking skin from the edge of the hairline behind the ear using a punch biopsy techniques. These are then placed in a machine that homogenises and releases stem cells. This is then re-injected into the scalp. This technique is also known as Micro-grafting. Our stem cell treatments at Rejuvence using a combination of Angel Arthrex PRP and nanofat (also known as stromal vascular fraction – SVF) harvesting amounts to the same end point. There is no evidence to suggest that one technique is superior to the other at present. With the increasing use of Exosomes like E50 some would argue that further developments along the lines of Regenera Activa and Nanofat/SVF harvesting may be futile.
