Erectile dysfunction (ED) is extremely common and affects millions of men worldwide. While medications such as PDE5 inhibitors remain first-line therapy, they do not treat the underlying causes of ED. In recent years, platelet-rich plasma (PRP) has emerged as a promising regenerative treatment capable of improving vascular health, repairing nerve tissue, and restoring erectile function.

A new 2024 systematic review and meta-analysis of randomised controlled trials (RCTs) — the highest level of clinical evidence — provides the strongest support yet for PRP as an effective therapy for ED.¹

Below, we summarise the findings and explain why Rejuvence Clinic’s P-Shot service, powered by Angel Arthrex PRP and our groundbreaking new ExoSmart autologous exosome system, offers one of the most advanced regenerative solutions in the UK.

What the Meta-Analysis Shows: PRP Works for Erectile Dysfunction

The study analysed 4 high-quality RCTs involving 343 men with ED. PRP was compared with placebo across multiple time points.

Key Findings

PRP significantly improved erectile function (IIEF scores) at 1 month, 3 months, and 6 months compared with placebo (all p < 0.00001).

1 The efficacy of platelet rich plasma in the treatment of erectile dysfunction: a systematic review and meta-analysis of randomized controlled trials. Qiancheng Mao, Yingying Yang, Yang Liu, Hongquan Liu, Gonglin Tang, Xiaofeng Wang, Yuanshan Cui & Jitao Wu. THE AGING MALE 2024, VOL. 27, NO. 1, 2358944

https://doi.org/10.1080/13685538.2024.2358944

Patients receiving PRP were far more likely to achieve a clinically meaningful improvement (MCID) at:
1 month (p =03)
6 months (p =008)
Improvements continued to increase over time, suggesting ongoing tissue
No serious side effects were reported in any study — PRP was well tolerated and

How Many Treatments Were Used in the Studies?

The RCTs included in the meta-analysis used:

2 PRP sessions (Poulios et)
3 PRP sessions (Shaher et)
Weekly PRP sessions combined with ESWT (Ruffo et )
Single paired injections of 5 mL per side (Masterson et al.)

This demonstrates that multiple PRP protocols can be effective, though consistency of PRP quality remains a major variable.r Erections

PRP contains:

Vascular endothelial growth factor (VEGF) – stimulates new blood vessel growth
Fibroblast & epidermal growth factors (FGF, EGF) – repair tissue
Nerve growth factor (NGF) – supports nerve regeneration
Anti-inflammatory and analgesic molecules These factors help rebuild:
Cavernosal smooth muscle
Vascular structures
Nerve pathways

This means PRP doesn’t just “boost erections” — it treats the root causes of ED.

A Key Limitation in Studies: Not All PRP Is the Same

The authors of the meta-analysis highlight a major issue:

“The preparation of PRP is not standardised… the platelet separation devices used vary, meaning platelet concentrations and growth-factor levels differ significantly”

This variation can dramatically affect treatment outcomes. Many commercial PRP systems deliver low platelet concentrations, inconsistent quality, and high red-cell contamination — reducing regenerative potential.

At Rejuvence Clinic: We Use the Angel Arthrex PRP System — Considered Superior in PRP Medicine

To ensure the highest possible efficacy for our P-Shot patients, we use the Angel Arthrex PRP system, widely regarded as the most advanced PRP technology available.

Why Angel Arthrex Is Superior

✔ Up to 18x platelet concentration — far higher than typical 2–5x systems used in many studies

✔ Micro-precision control of red & white blood cell content — extremely low contamination

✔ Consistent, reproducible PRP quality — crucial for clinical success

✔ Fully closed sterile system — maximum safety

Compared with the PRP systems used across the studies in the meta-analysis — many of which used basic centrifuges or non-customisable kits — Angel Arthrex provides:

Higher platelet yields
Higher concentrations of VEGF, PDGF, IGF, and other growth factors
More controlled PRP composition

This results in stronger and more predictable regenerative effects, naturally supporting better erectile function outcomes

Introducing ExoSmart — The First Autologous Exosome Therapy Integrated With Angel Arthrex in the UK

Rejuvence Clinic is the first clinic in the UK to combine Angel Arthrex PRP with ExoSmart, an innovative new autologous exosome system.

What ExoSmart Adds

ExoSmart isolates highly bioactive nano-vesicles (exosomes) carrying:

Vascular endothelial growth factor (VEGF)
Insulin-like growth factor (IGF)
Transforming growth factor (TGF-β)
Cytokines that signal cellular repair

These exosomes:

Enhance tissue regeneration
Stimulate angiogenesis
Boost nerve repair
Amplify the bioactivity of PRP

Together, Angel Arthrex + ExoSmart forms one of the most potent, personalised regenerative solutions available globally.

The Rejuvence Clinic P-Shot: A

Next-Generation Regenerative Treatment

Our P-Shot service leverages:

Angel Arthrex high-concentration PRP
ExoSmart autologous exosomes
Precision ultrasound-guided delivery
Protocols informed by the latest RCT evidence

Why Patients Choose Rejuvence Clinic

✔ Higher growth-factor levels than systems used in published studies

✔ Evidence-based treatment protocols

✔ Enhanced healing and erectile restoration

✔ First clinic in the UK to combine Angel Arthrex with ExoSmart

✔ Safe, autologous, non-surgical approach

Our approach directly addresses the core pathology behind ED — vascular insufficiency, smooth muscle degeneration, and nerve dysfunction.

Conclusion: PRP Is Effective — and Rejuvence Clinic Offers the Most Advanced Version Available

The latest meta-analysis confirms what clinicians worldwide are observing:

PRP significantly improves erectile function and is a safe, effective therapy for ED. But quality matters.

The PRP systems used in the published RCTs vary widely — and many deliver relatively low platelet concentrations.

At Rejuvence Clinic, we go beyond traditional PRP:

Angel Arthrex PRP provides unmatched platelet and growth-factor
ExoSmart autologous exosomes offer an additional regenerative signal
Combined, they create a powerful, next-generation treatment for

If you’re looking for a regenerative solution with superior biological potency and clinical precision, the Rejuvence P-Shot is at the leading edge of modern male sexual-health medicine.